研究でcobraライブラリを使用して化学反応ネットワークを最適化する機会があったので、データ抽出等の記録をしておきます。
データマイニング
BiGGデータベースからStoichiometic Matrixを作成するコードを作成しました。
具体的には、EcoliCore代謝マップのXMLファイルを拾ってきて、化学反応式の係数行列をcsvファイルとして出力するプログラムを作成しました。
import cobra
from cobra import Metabolite, Reaction
model = cobra.io.read_sbml_model("e_coli_core.xml")
mtobjects:list[Metabolite] = model.metabolites
tmp:list] = [[j for j in i.reactions] for i in mtobjects]
metabolite_ids:list[str] = []
for i in tmp:
for j in i:
# print(j.objective_coefficient)
# print(j.reaction)
# print(j.metabolites.values())
print("###########################################")
print(f"Reaction: {j.reaction}")
print(f"Reaction: {j.id}")
# for metabolite, coefficient in j.metabolites.items():
# metabolite_formula = metabolite.formula if metabolite.formula else "N/A" # 分子式が存在しない場合は "N/A" と表示する
# print("係数:", coefficient, "分子式:", metabolite_formula)
for metabolite, coefficient in j.metabolites.items():
metabolite_id = metabolite.id
metabolite_ids.append(metabolite_id)
print("係数:", coefficient, "化合物id:", metabolite_id)
metabolite_ids = sorted(list(set(metabolite_ids)))
print(metabolite_ids)
S = []
for i in tmp:
S_i = []
for j in i:
S_i.append(j.id)
reaction = {i[0].id:float(i[1]) for i in list(j.metabolites.items())}
print(reaction)
tp = [reaction[i] if i in list(reaction.keys()) else 0.0 for i in metabolite_ids ]
S_i += tp
S.append(S_i)
for i in S:
print(i)
with open("data.csv","w") as fpout:
fpout.write(f"{','.join([' ']+metabolite_ids)}\n")
for i in S:
fpout.write(f"{','.join([str(i) for i in i])}\n")
>>>
Reaction: PTAr
係数: -1.0 化合物id: accoa_c
係数: -1.0 化合物id: pi_c
係数: 1.0 化合物id: actp_c
係数: 1.0 化合物id: coa_c
###########################################
Reaction: accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c
Reaction: CS
係数: -1.0 化合物id: accoa_c
係数: -1.0 化合物id: h2o_c
係数: -1.0 化合物id: oaa_c
係数: 1.0 化合物id: cit_c
係数: 1.0 化合物id: coa_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c
Reaction: MALS
係数: -1.0 化合物id: accoa_c
係数: -1.0 化合物id: glx_c
係数: -1.0 化合物id: h2o_c
係数: 1.0 化合物id: coa_c
係数: 1.0 化合物id: h_c
係数: 1.0 化合物id: mal__L_c
###########################################
Reaction: 1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c
Reaction: BIOMASS_Ecoli_core_w_GAM
係数: -1.496 化合物id: 3pg_c
係数: -3.7478 化合物id: accoa_c
係数: -59.81 化合物id: atp_c
係数: -0.361 化合物id: e4p_c
係数: -0.0709 化合物id: f6p_c
係数: -0.129 化合物id: g3p_c
係数: -0.205 化合物id: g6p_c
係数: -0.2557 化合物id: gln__L_c
係数: -4.9414 化合物id: glu__L_c
係数: -59.81 化合物id: h2o_c
係数: -3.547 化合物id: nad_c
係数: -13.0279 化合物id: nadph_c
係数: -1.7867 化合物id: oaa_c
係数: -0.5191 化合物id: pep_c
係数: -2.8328 化合物id: pyr_c
係数: -0.8977 化合物id: r5p_c
係数: 59.81 化合物id: adp_c
係数: 4.1182 化合物id: akg_c
係数: 3.7478 化合物id: coa_c
係数: 59.81 化合物id: h_c
係数: 3.547 化合物id: nadh_c
係数: 13.0279 化合物id: nadp_c
係数: 59.81 化合物id: pi_c
###########################################
Reaction: akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c
Reaction: AKGDH
係数: -1.0 化合物id: akg_c
係数: -1.0 化合物id: coa_c
係数: -1.0 化合物id: nad_c
係数: 1.0 化合物id: co2_c
係数: 1.0 化合物id: nadh_c
係数: 1.0 化合物id: succoa_c
###########################################
Reaction: coa_c + pyr_c --> accoa_c + for_c
Reaction: PFL
係数: -1.0 化合物id: coa_c
係数: -1.0 化合物id: pyr_c
係数: 1.0 化合物id: accoa_c
係数: 1.0 化合物id: for_c
###########################################
Reaction: coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c
Reaction: PDH
係数: -1.0 化合物id: coa_c
係数: -1.0 化合物id: nad_c
係数: -1.0 化合物id: pyr_c
係数: 1.0 化合物id: accoa_c
係数: 1.0 化合物id: co2_c
係数: 1.0 化合物id: nadh_c
###########################################
Reaction: acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c
Reaction: ACALD
係数: -1.0 化合物id: acald_c
係数: -1.0 化合物id: coa_c
係数: -1.0 化合物id: nad_c
係数: 1.0 化合物id: accoa_c
係数: 1.0 化合物id: h_c
係数: 1.0 化合物id: nadh_c
###########################################
Reaction: dhap_c <=> g3p_c
Reaction: TPI
係数: -1.0 化合物id: dhap_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: fdp_c <=> dhap_c + g3p_c
Reaction: FBA
係数: -1.0 化合物id: fdp_c
係数: 1.0 化合物id: dhap_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: e4p_c + xu5p__D_c <=> f6p_c + g3p_c
Reaction: TKT2
係数: -1.0 化合物id: e4p_c
係数: -1.0 化合物id: xu5p__D_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: g3p_c + s7p_c <=> e4p_c + f6p_c
Reaction: TALA
係数: -1.0 化合物id: g3p_c
係数: -1.0 化合物id: s7p_c
係数: 1.0 化合物id: e4p_c
係数: 1.0 化合物id: f6p_c
###########################################
Reaction: 1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c
Reaction: BIOMASS_Ecoli_core_w_GAM
係数: -1.496 化合物id: 3pg_c
係数: -3.7478 化合物id: accoa_c
係数: -59.81 化合物id: atp_c
係数: -0.361 化合物id: e4p_c
係数: -0.0709 化合物id: f6p_c
係数: -0.129 化合物id: g3p_c
係数: -0.205 化合物id: g6p_c
係数: -0.2557 化合物id: gln__L_c
係数: -4.9414 化合物id: glu__L_c
係数: -59.81 化合物id: h2o_c
係数: -3.547 化合物id: nad_c
係数: -13.0279 化合物id: nadph_c
係数: -1.7867 化合物id: oaa_c
係数: -0.5191 化合物id: pep_c
係数: -2.8328 化合物id: pyr_c
係数: -0.8977 化合物id: r5p_c
係数: 59.81 化合物id: adp_c
係数: 4.1182 化合物id: akg_c
係数: 3.7478 化合物id: coa_c
係数: 59.81 化合物id: h_c
係数: 3.547 化合物id: nadh_c
係数: 13.0279 化合物id: nadp_c
係数: 59.81 化合物id: pi_c
###########################################
Reaction: etoh_e + h_e <=> etoh_c + h_c
Reaction: ETOHt2r
係数: -1.0 化合物id: etoh_e
係数: -1.0 化合物id: h_e
係数: 1.0 化合物id: etoh_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: etoh_c + nad_c <=> acald_c + h_c + nadh_c
Reaction: ALCD2x
係数: -1.0 化合物id: etoh_c
係数: -1.0 化合物id: nad_c
係数: 1.0 化合物id: acald_c
係数: 1.0 化合物id: h_c
係数: 1.0 化合物id: nadh_c
###########################################
Reaction: etoh_e + h_e <=> etoh_c + h_c
Reaction: ETOHt2r
係数: -1.0 化合物id: etoh_e
係数: -1.0 化合物id: h_e
係数: 1.0 化合物id: etoh_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: etoh_e -->
Reaction: EX_etoh_e
係数: -1.0 化合物id: etoh_e
###########################################
Reaction: g6p_c <=> f6p_c
Reaction: PGI
係数: -1.0 化合物id: g6p_c
係数: 1.0 化合物id: f6p_c
###########################################
Reaction: e4p_c + xu5p__D_c <=> f6p_c + g3p_c
Reaction: TKT2
係数: -1.0 化合物id: e4p_c
係数: -1.0 化合物id: xu5p__D_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: 1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c
Reaction: BIOMASS_Ecoli_core_w_GAM
係数: -1.496 化合物id: 3pg_c
係数: -3.7478 化合物id: accoa_c
係数: -59.81 化合物id: atp_c
係数: -0.361 化合物id: e4p_c
係数: -0.0709 化合物id: f6p_c
係数: -0.129 化合物id: g3p_c
係数: -0.205 化合物id: g6p_c
係数: -0.2557 化合物id: gln__L_c
係数: -4.9414 化合物id: glu__L_c
係数: -59.81 化合物id: h2o_c
係数: -3.547 化合物id: nad_c
係数: -13.0279 化合物id: nadph_c
係数: -1.7867 化合物id: oaa_c
係数: -0.5191 化合物id: pep_c
係数: -2.8328 化合物id: pyr_c
係数: -0.8977 化合物id: r5p_c
係数: 59.81 化合物id: adp_c
係数: 4.1182 化合物id: akg_c
係数: 3.7478 化合物id: coa_c
係数: 59.81 化合物id: h_c
係数: 3.547 化合物id: nadh_c
係数: 13.0279 化合物id: nadp_c
係数: 59.81 化合物id: pi_c
###########################################
Reaction: fdp_c + h2o_c --> f6p_c + pi_c
Reaction: FBP
係数: -1.0 化合物id: fdp_c
係数: -1.0 化合物id: h2o_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: pi_c
###########################################
Reaction: fru_e + pep_c --> f6p_c + pyr_c
Reaction: FRUpts2
係数: -1.0 化合物id: fru_e
係数: -1.0 化合物id: pep_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: pyr_c
###########################################
Reaction: g3p_c + s7p_c <=> e4p_c + f6p_c
Reaction: TALA
係数: -1.0 化合物id: g3p_c
係数: -1.0 化合物id: s7p_c
係数: 1.0 化合物id: e4p_c
係数: 1.0 化合物id: f6p_c
###########################################
Reaction: atp_c + f6p_c --> adp_c + fdp_c + h_c
Reaction: PFK
係数: -1.0 化合物id: atp_c
係数: -1.0 化合物id: f6p_c
係数: 1.0 化合物id: adp_c
係数: 1.0 化合物id: fdp_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: fdp_c <=> dhap_c + g3p_c
Reaction: FBA
係数: -1.0 化合物id: fdp_c
係数: 1.0 化合物id: dhap_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: fdp_c + h2o_c --> f6p_c + pi_c
Reaction: FBP
係数: -1.0 化合物id: fdp_c
係数: -1.0 化合物id: h2o_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: pi_c
###########################################
Reaction: atp_c + f6p_c --> adp_c + fdp_c + h_c
Reaction: PFK
係数: -1.0 化合物id: atp_c
係数: -1.0 化合物id: f6p_c
係数: 1.0 化合物id: adp_c
係数: 1.0 化合物id: fdp_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: for_e <-- for_c
Reaction: FORt
係数: -1.0 化合物id: for_e
係数: 1.0 化合物id: for_c
###########################################
Reaction: for_e + h_e --> for_c + h_c
Reaction: FORt2
係数: -1.0 化合物id: for_e
係数: -1.0 化合物id: h_e
係数: 1.0 化合物id: for_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: coa_c + pyr_c --> accoa_c + for_c
Reaction: PFL
係数: -1.0 化合物id: coa_c
係数: -1.0 化合物id: pyr_c
係数: 1.0 化合物id: accoa_c
係数: 1.0 化合物id: for_c
###########################################
Reaction: for_e -->
Reaction: EX_for_e
係数: -1.0 化合物id: for_e
###########################################
Reaction: for_e <-- for_c
Reaction: FORt
係数: -1.0 化合物id: for_e
係数: 1.0 化合物id: for_c
###########################################
Reaction: for_e + h_e --> for_c + h_c
Reaction: FORt2
係数: -1.0 化合物id: for_e
係数: -1.0 化合物id: h_e
係数: 1.0 化合物id: for_c
係数: 1.0 化合物id: h_c
###########################################
Reaction: fru_e -->
Reaction: EX_fru_e
係数: -1.0 化合物id: fru_e
###########################################
Reaction: fru_e + pep_c --> f6p_c + pyr_c
Reaction: FRUpts2
係数: -1.0 化合物id: fru_e
係数: -1.0 化合物id: pep_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: pyr_c
###########################################
Reaction: q8_c + succ_c --> fum_c + q8h2_c
Reaction: SUCDi
係数: -1.0 化合物id: q8_c
係数: -1.0 化合物id: succ_c
係数: 1.0 化合物id: fum_c
係数: 1.0 化合物id: q8h2_c
###########################################
Reaction: fum_c + h2o_c <=> mal__L_c
Reaction: FUM
係数: -1.0 化合物id: fum_c
係数: -1.0 化合物id: h2o_c
係数: 1.0 化合物id: mal__L_c
###########################################
Reaction: fum_c + q8h2_c --> q8_c + succ_c
Reaction: FRD7
係数: -1.0 化合物id: fum_c
係数: -1.0 化合物id: q8h2_c
係数: 1.0 化合物id: q8_c
係数: 1.0 化合物id: succ_c
###########################################
Reaction: fum_e + 2.0 h_e --> fum_c + 2.0 h_c
Reaction: FUMt2_2
係数: -1.0 化合物id: fum_e
係数: -2.0 化合物id: h_e
係数: 1.0 化合物id: fum_c
係数: 2.0 化合物id: h_c
###########################################
Reaction: fum_e + 2.0 h_e --> fum_c + 2.0 h_c
Reaction: FUMt2_2
係数: -1.0 化合物id: fum_e
係数: -2.0 化合物id: h_e
係数: 1.0 化合物id: fum_c
係数: 2.0 化合物id: h_c
###########################################
Reaction: fum_e -->
Reaction: EX_fum_e
係数: -1.0 化合物id: fum_e
###########################################
Reaction: dhap_c <=> g3p_c
Reaction: TPI
係数: -1.0 化合物id: dhap_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: fdp_c <=> dhap_c + g3p_c
Reaction: FBA
係数: -1.0 化合物id: fdp_c
係数: 1.0 化合物id: dhap_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: e4p_c + xu5p__D_c <=> f6p_c + g3p_c
Reaction: TKT2
係数: -1.0 化合物id: e4p_c
係数: -1.0 化合物id: xu5p__D_c
係数: 1.0 化合物id: f6p_c
係数: 1.0 化合物id: g3p_c
###########################################
Reaction: 1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c
Reaction: BIOMASS_Ecoli_core_w_GAM
係数: -1.496 化合物id: 3pg_c
係数: -3.7478 化合物id: accoa_c
係数: -59.81 化合物id: atp_c
係数: -0.361 化合物id: e4p_c
係数: -0.0709 化合物id: f6p_c
係数: -0.129 化合物id: g3p_c
係数: -0.205 化合物id: g6p_c
係数: -0.2557 化合物id: gln__L_c
係数: -4.9414 化合物id: glu__L_c
係数: -59.81 化合物id: h2o_c
係数: -3.547 化合物id: nad_c
係数: -13.0279 化合物id: nadph_c
係数: -1.7867 化合物id: oaa_c
係数: -0.5191 化合物id: pep_c
係数: -2.8328 化合物id: pyr_c
係数: -0.8977 化合物id: r5p_c
係数: 59.81 化合物id: adp_c
係数: 4.1182 化合物id: akg_c
係数: 3.7478 化合物id: coa_c
係数: 59.81 化合物id: h_c
係数: 3.547 化合物id: nadh_c
係数: 13.0279 化合物id: nadp_c
係数: 59.81 化合物id: pi_c
###########################################
Reaction: g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c
Reaction: GAPD
係数: -1.0 化合物id: g3p_c
係数: -1.0 化合物id: nad_c
係数: -1.0 化合物id: pi_c
係数: 1.0 化合物id: 13dpg_c
係数: 1.0 化合物id: h_c
係数: 1.0 化合物id: nadh_c
###########################################
Reaction: r5p_c + xu5p__D_c <=> g3p_c + s7p_c
Reaction: TKT1
係数: -1.0 化合物id: r5p_c
係数: -1.0 化合物id: xu5p__D_c
係数: 1.0 化合物id: g3p_c
係数: 1.0 化合物id: s7p_c
###########################################
Reaction: g3p_c + s7p_c <=> e4p_c + f6p_c
Reaction: TALA
係数: -1.0 化合物id: g3p_c
係数: -1.0 化合物id: s7p_c
係数: 1.0 化合物id: e4p_c
係数: 1.0 化合物id: f6p_c
###########################################
Reaction: glc__D_e + pep_c --> g6p_c + pyr_c
Reaction: GLCpts
係数: -1.0 化合物id: glc__D_e
係数: -1.0 化合物id: pep_c
係数: 1.0 化合物id: g6p_c
係数: 1.0 化合物id: pyr_c
###########################################
Reaction: g6p_c <=> f6p_c
Reaction: PGI
係数: -1.0 化合物id: g6p_c
係数: 1.0 化合物id: f6p_c
###########################################
Reaction: g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c
Reaction: G6PDH2r
係数: -1.0 化合物id: g6p_c
係数: -1.0 化合物id: nadp_c
係数: 1.0 化合物id: 6pgl_c
係数: 1.0 化合物id: h_c
係数: 1.0 化合物id: nadph_c
###########################################
Reaction: 1.496 3pg_c + 3.7478 accoa_c + 59.81 atp_c + 0.361 e4p_c + 0.0709 f6p_c + 0.129 g3p_c + 0.205 g6p_c + 0.2557 gln__L_c + 4.9414 glu__L_c + 59.81 h2o_c + 3.547 nad_c + 13.0279 nadph_c + 1.7867 oaa_c + 0.5191 pep_c + 2.8328 pyr_c + 0.8977 r5p_c --> 59.81 adp_c + 4.1182 akg_c + 3.7478 coa_c + 59.81 h_c + 3.547 nadh_c + 13.0279 nadp_c + 59.81 pi_c
Reaction: BIOMASS_Ecoli_core_w_GAM
係数: -1.496 化合物id: 3pg_c
係数: -3.7478 化合物id: accoa_c
係数: -59.81 化合物id: atp_c
係数: -0.361 化合物id: e4p_c
係数: -0.0709 化合物id: f6p_c
係数: -0.129 化合物id: g3p_c
係数: -0.205 化合物id: g6p_c
係数: -0.2557 化合物id: gln__L_c
係数: -4.9414 化合物id: glu__L_c
係数: -59.81 化合物id: h2o_c
係数: -3.547 化合物id: nad_c
係数: -13.0279 化合物id: nadph_c
係数: -1.7867 化合物id: oaa_c
係数: -0.5191 化合物id: pep_c
係数: -2.8328 化合物id: pyr_c
係数: -0.8977 化合物id: r5p_c
係数: 59.81 化合物id: adp_c
係数: 4.1182 化合物id: akg_c
係数: 3.7478 化合物id: coa_c
係数: 59.81 化合物id: h_c
係数: 3.547 化合物id: nadh_c
係数: 13.0279 化合物id: nadp_c
係数: 59.81 化合物id: pi_c
['g3p_c', 'mal__L_e', 'h_c', 'akg_c', 'etoh_c', 'ru5p__D_c', 'q8_c', 'pyr_c', 'oaa_c', 'icit_c', '6pgc_c', '6pgl_c', 'nad_c', '13dpg_c', 'mal__L_c', 'f6p_c', 'fru_e', 'succ_c', 'for_e', 's7p_c', 'adp_c', 'etoh_e', 'xu5p__D_c', 'succ_e', 'fdp_c', 'dhap_c', 'glu__L_c', 'for_c', 'gln__L_e', 'fum_c', 'acon_C_c', 'akg_e', 'accoa_c', 'pyr_e', 'ac_e', 'glc__D_e', 'lac__D_c', 'nh4_e', 'e4p_c', '2pg_c', 'pep_c', 'co2_e', 'h2o_e', 'actp_c', 'gln__L_c', 'nh4_c', 'amp_c', 'glx_c', 'cit_c', 'q8h2_c', 'glu__L_e', 'h2o_c', 'acald_c', 'fum_e', 'nadph_c', 'h_e', 'succoa_c', 'lac__D_e', 'atp_c', 'pi_e', 'nadp_c', 'coa_c', 'o2_e', 'acald_e', 'co2_c', 'o2_c', 'pi_c', 'r5p_c', 'ac_c', 'nadh_c', 'g6p_c', '3pg_c']
{'glc__D_e': -1.0, 'pep_c': -1.0, 'g6p_c': 1.0, 'pyr_c': 1.0}
{'glc__D_e': -1.0}
{'gln__L_c': -1.0, 'h2o_c': -1.0, 'glu__L_c': 1.0, 'nh4_c': 1.0}
{'akg_c': -1.0, 'gln__L_c': -1.0, 'h_c': -1.0, 'nadph_c': -1.0, 'glu__L_c': 2.0, 'nadp_c': 1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'gln__L_e': -1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'gln__L_c': -1.0, 'h2o_c': -1.0, 'glu__L_c': 1.0, 'nh4_c': 1.0}
{'akg_c': -1.0, 'gln__L_c': -1.0, 'h_c': -1.0, 'nadph_c': -1.0, 'glu__L_c': 2.0, 'nadp_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'glu__L_e': -1.0, 'h_e': -1.0, 'glu__L_c': 1.0, 'h_c': 1.0}
{'glu__L_e': -1.0}
{'glu__L_e': -1.0, 'h_e': -1.0, 'glu__L_c': 1.0, 'h_c': 1.0}
{'accoa_c': -1.0, 'glx_c': -1.0, 'h2o_c': -1.0, 'coa_c': 1.0, 'h_c': 1.0, 'mal__L_c': 1.0}
{'icit_c': -1.0, 'glx_c': 1.0, 'succ_c': 1.0}
{'cit_c': -1.0, 'acon_C_c': 1.0, 'h2o_c': 1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'6pgl_c': -1.0, 'h2o_c': -1.0, '6pgc_c': 1.0, 'h_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'accoa_c': -1.0, 'h2o_c': -1.0, 'oaa_c': -1.0, 'cit_c': 1.0, 'coa_c': 1.0, 'h_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'accoa_c': -1.0, 'glx_c': -1.0, 'h2o_c': -1.0, 'coa_c': 1.0, 'h_c': 1.0, 'mal__L_c': 1.0}
{'2pg_c': -1.0, 'h2o_c': 1.0, 'pep_c': 1.0}
{'gln__L_c': -1.0, 'h2o_c': -1.0, 'glu__L_c': 1.0, 'nh4_c': 1.0}
{'co2_c': -1.0, 'h2o_c': -1.0, 'pep_c': -1.0, 'h_c': 1.0, 'oaa_c': 1.0, 'pi_c': 1.0}
{'adp_c': -1.0, 'h_e': -4.0, 'pi_c': -1.0, 'atp_c': 1.0, 'h2o_c': 1.0, 'h_c': 3.0}
{'acon_C_c': -1.0, 'h2o_c': -1.0, 'icit_c': 1.0}
{'h_c': -2.0, 'o2_c': -0.5, 'q8h2_c': -1.0, 'h2o_c': 1.0, 'h_e': 2.0, 'q8_c': 1.0}
{'fdp_c': -1.0, 'h2o_c': -1.0, 'f6p_c': 1.0, 'pi_c': 1.0}
{'fum_c': -1.0, 'h2o_c': -1.0, 'mal__L_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'h2o_e': -1.0, 'h2o_c': 1.0}
{'h2o_e': -1.0, 'h2o_c': 1.0}
{'h2o_e': -1.0}
{'h_e': -2.0, 'mal__L_e': -1.0, 'h_c': 2.0, 'mal__L_c': 1.0}
{'for_e': -1.0, 'h_e': -1.0, 'for_c': 1.0, 'h_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'akg_e': -1.0, 'h_e': -1.0, 'akg_c': 1.0, 'h_c': 1.0}
{'atp_c': -1.0, 'f6p_c': -1.0, 'adp_c': 1.0, 'fdp_c': 1.0, 'h_c': 1.0}
{'glu__L_e': -1.0, 'h_e': -1.0, 'glu__L_c': 1.0, 'h_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'ac_e': -1.0, 'h_e': -1.0, 'ac_c': 1.0, 'h_c': 1.0}
{'acald_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'accoa_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'etoh_e': -1.0, 'h_e': -1.0, 'etoh_c': 1.0, 'h_c': 1.0}
{'akg_c': -1.0, 'gln__L_c': -1.0, 'h_c': -1.0, 'nadph_c': -1.0, 'glu__L_c': 2.0, 'nadp_c': 1.0}
{'h_e': -1.0, 'pi_e': -1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'h_c': -4.0, 'nadh_c': -1.0, 'q8_c': -1.0, 'h_e': 3.0, 'nad_c': 1.0, 'q8h2_c': 1.0}
{'adp_c': -1.0, 'h_e': -4.0, 'pi_c': -1.0, 'atp_c': 1.0, 'h2o_c': 1.0, 'h_c': 3.0}
{'h_e': -1.0, 'succ_c': -1.0, 'h_c': 1.0, 'succ_e': 1.0}
{'h_e': -2.0, 'nadh_c': -1.0, 'nadp_c': -1.0, 'h_c': 2.0, 'nad_c': 1.0, 'nadph_c': 1.0}
{'h_c': -2.0, 'o2_c': -0.5, 'q8h2_c': -1.0, 'h2o_c': 1.0, 'h_e': 2.0, 'q8_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'oaa_c': 1.0}
{'h_e': -1.0, 'pyr_e': -1.0, 'h_c': 1.0, 'pyr_c': 1.0}
{'adp_c': -1.0, 'h_c': -1.0, 'pep_c': -1.0, 'atp_c': 1.0, 'pyr_c': 1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'6pgl_c': -1.0, 'h2o_c': -1.0, '6pgc_c': 1.0, 'h_c': 1.0}
{'accoa_c': -1.0, 'h2o_c': -1.0, 'oaa_c': -1.0, 'cit_c': 1.0, 'coa_c': 1.0, 'h_c': 1.0}
{'h_e': -1.0, 'lac__D_e': -1.0, 'h_c': 1.0, 'lac__D_c': 1.0}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'g3p_c': -1.0, 'nad_c': -1.0, 'pi_c': -1.0, '13dpg_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'accoa_c': -1.0, 'glx_c': -1.0, 'h2o_c': -1.0, 'coa_c': 1.0, 'h_c': 1.0, 'mal__L_c': 1.0}
{'h_e': -2.0, 'succ_e': -1.0, 'h_c': 2.0, 'succ_c': 1.0}
{'co2_c': -1.0, 'h2o_c': -1.0, 'pep_c': -1.0, 'h_c': 1.0, 'oaa_c': 1.0, 'pi_c': 1.0}
{'fum_e': -1.0, 'h_e': -2.0, 'fum_c': 1.0, 'h_c': 2.0}
{'etoh_c': -1.0, 'nad_c': -1.0, 'acald_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'lac__D_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'g6p_c': -1.0, 'nadp_c': -1.0, '6pgl_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0}
{'h_e': -1.0, 'pyr_e': -1.0, 'h_c': 1.0, 'pyr_c': 1.0}
{'h_e': -2.0, 'mal__L_e': -1.0, 'h_c': 2.0, 'mal__L_c': 1.0}
{'for_e': -1.0, 'h_e': -1.0, 'for_c': 1.0, 'h_c': 1.0}
{'akg_e': -1.0, 'h_e': -1.0, 'akg_c': 1.0, 'h_c': 1.0}
{'glu__L_e': -1.0, 'h_e': -1.0, 'glu__L_c': 1.0, 'h_c': 1.0}
{'h_e': -1.0, 'lac__D_e': -1.0, 'h_c': 1.0, 'lac__D_c': 1.0}
{'h_e': -1.0}
{'ac_e': -1.0, 'h_e': -1.0, 'ac_c': 1.0, 'h_c': 1.0}
{'h_e': -2.0, 'succ_e': -1.0, 'h_c': 2.0, 'succ_c': 1.0}
{'etoh_e': -1.0, 'h_e': -1.0, 'etoh_c': 1.0, 'h_c': 1.0}
{'h_e': -1.0, 'pi_e': -1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'fum_e': -1.0, 'h_e': -2.0, 'fum_c': 1.0, 'h_c': 2.0}
{'h_c': -4.0, 'nadh_c': -1.0, 'q8_c': -1.0, 'h_e': 3.0, 'nad_c': 1.0, 'q8h2_c': 1.0}
{'adp_c': -1.0, 'h_e': -4.0, 'pi_c': -1.0, 'atp_c': 1.0, 'h2o_c': 1.0, 'h_c': 3.0}
{'h_e': -1.0, 'succ_c': -1.0, 'h_c': 1.0, 'succ_e': 1.0}
{'h_e': -2.0, 'nadh_c': -1.0, 'nadp_c': -1.0, 'h_c': 2.0, 'nad_c': 1.0, 'nadph_c': 1.0}
{'h_c': -2.0, 'o2_c': -0.5, 'q8h2_c': -1.0, 'h2o_c': 1.0, 'h_e': 2.0, 'q8_c': 1.0}
{'icit_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'co2_c': 1.0, 'nadph_c': 1.0}
{'acon_C_c': -1.0, 'h2o_c': -1.0, 'icit_c': 1.0}
{'icit_c': -1.0, 'glx_c': 1.0, 'succ_c': 1.0}
{'h_e': -1.0, 'lac__D_e': -1.0, 'h_c': 1.0, 'lac__D_c': 1.0}
{'lac__D_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'h_e': -1.0, 'lac__D_e': -1.0, 'h_c': 1.0, 'lac__D_c': 1.0}
{'lac__D_e': -1.0}
{'h_e': -2.0, 'mal__L_e': -1.0, 'h_c': 2.0, 'mal__L_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'accoa_c': -1.0, 'glx_c': -1.0, 'h2o_c': -1.0, 'coa_c': 1.0, 'h_c': 1.0, 'mal__L_c': 1.0}
{'fum_c': -1.0, 'h2o_c': -1.0, 'mal__L_c': 1.0}
{'mal__L_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'pyr_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'oaa_c': 1.0}
{'h_e': -2.0, 'mal__L_e': -1.0, 'h_c': 2.0, 'mal__L_c': 1.0}
{'mal__L_e': -1.0}
{'nad_c': -1.0, 'nadph_c': -1.0, 'nadh_c': 1.0, 'nadp_c': 1.0}
{'h_c': -4.0, 'nadh_c': -1.0, 'q8_c': -1.0, 'h_e': 3.0, 'nad_c': 1.0, 'q8h2_c': 1.0}
{'etoh_c': -1.0, 'nad_c': -1.0, 'acald_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'lac__D_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'oaa_c': 1.0}
{'h_e': -2.0, 'nadh_c': -1.0, 'nadp_c': -1.0, 'h_c': 2.0, 'nad_c': 1.0, 'nadph_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'akg_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'succoa_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'g3p_c': -1.0, 'nad_c': -1.0, 'pi_c': -1.0, '13dpg_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'coa_c': -1.0, 'nad_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'co2_c': 1.0, 'nadh_c': 1.0}
{'acald_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'accoa_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'nad_c': -1.0, 'nadph_c': -1.0, 'nadh_c': 1.0, 'nadp_c': 1.0}
{'h_c': -4.0, 'nadh_c': -1.0, 'q8_c': -1.0, 'h_e': 3.0, 'nad_c': 1.0, 'q8h2_c': 1.0}
{'etoh_c': -1.0, 'nad_c': -1.0, 'acald_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'lac__D_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'oaa_c': 1.0}
{'h_e': -2.0, 'nadh_c': -1.0, 'nadp_c': -1.0, 'h_c': 2.0, 'nad_c': 1.0, 'nadph_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'akg_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'succoa_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'g3p_c': -1.0, 'nad_c': -1.0, 'pi_c': -1.0, '13dpg_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'coa_c': -1.0, 'nad_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'co2_c': 1.0, 'nadh_c': 1.0}
{'acald_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'accoa_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'akg_c': -1.0, 'gln__L_c': -1.0, 'h_c': -1.0, 'nadph_c': -1.0, 'glu__L_c': 2.0, 'nadp_c': 1.0}
{'icit_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'co2_c': 1.0, 'nadph_c': 1.0}
{'nad_c': -1.0, 'nadph_c': -1.0, 'nadh_c': 1.0, 'nadp_c': 1.0}
{'h_e': -2.0, 'nadh_c': -1.0, 'nadp_c': -1.0, 'h_c': 2.0, 'nad_c': 1.0, 'nadph_c': 1.0}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'6pgc_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'ru5p__D_c': 1.0}
{'mal__L_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'pyr_c': 1.0}
{'g6p_c': -1.0, 'nadp_c': -1.0, '6pgl_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0}
{'akg_c': -1.0, 'gln__L_c': -1.0, 'h_c': -1.0, 'nadph_c': -1.0, 'glu__L_c': 2.0, 'nadp_c': 1.0}
{'icit_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'co2_c': 1.0, 'nadph_c': 1.0}
{'nad_c': -1.0, 'nadph_c': -1.0, 'nadh_c': 1.0, 'nadp_c': 1.0}
{'h_e': -2.0, 'nadh_c': -1.0, 'nadp_c': -1.0, 'h_c': 2.0, 'nad_c': 1.0, 'nadph_c': 1.0}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'6pgc_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'ru5p__D_c': 1.0}
{'mal__L_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'pyr_c': 1.0}
{'g6p_c': -1.0, 'nadp_c': -1.0, '6pgl_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0}
{'nh4_e': -1.0, 'nh4_c': 1.0}
{'gln__L_c': -1.0, 'h2o_c': -1.0, 'glu__L_c': 1.0, 'nh4_c': 1.0}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'g3p_c': -1.0, 'nad_c': -1.0, 'pi_c': -1.0, '13dpg_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'3pg_c': -1.0, 'atp_c': -1.0, '13dpg_c': 1.0, 'adp_c': 1.0}
{'nh4_e': -1.0, 'nh4_c': 1.0}
{'nh4_e': -1.0}
{'o2_e': -1.0, 'o2_c': 1.0}
{'h_c': -2.0, 'o2_c': -0.5, 'q8h2_c': -1.0, 'h2o_c': 1.0, 'h_e': 2.0, 'q8_c': 1.0}
{'2pg_c': -1.0, '3pg_c': 1.0}
{'2pg_c': -1.0, 'h2o_c': 1.0, 'pep_c': 1.0}
{'o2_e': -1.0, 'o2_c': 1.0}
{'o2_e': -1.0}
{'3pg_c': -1.0, 'atp_c': -1.0, '13dpg_c': 1.0, 'adp_c': 1.0}
{'2pg_c': -1.0, '3pg_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'co2_c': -1.0, 'h2o_c': -1.0, 'pep_c': -1.0, 'h_c': 1.0, 'oaa_c': 1.0, 'pi_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'atp_c': -1.0, 'oaa_c': -1.0, 'adp_c': 1.0, 'co2_c': 1.0, 'pep_c': 1.0}
{'accoa_c': -1.0, 'h2o_c': -1.0, 'oaa_c': -1.0, 'cit_c': 1.0, 'coa_c': 1.0, 'h_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'oaa_c': 1.0}
{'adp_c': -1.0, 'h_c': -1.0, 'pep_c': -1.0, 'atp_c': 1.0, 'pyr_c': 1.0}
{'co2_c': -1.0, 'h2o_c': -1.0, 'pep_c': -1.0, 'h_c': 1.0, 'oaa_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'oaa_c': -1.0, 'adp_c': 1.0, 'co2_c': 1.0, 'pep_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'fru_e': -1.0, 'pep_c': -1.0, 'f6p_c': 1.0, 'pyr_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'glc__D_e': -1.0, 'pep_c': -1.0, 'g6p_c': 1.0, 'pyr_c': 1.0}
{'2pg_c': -1.0, 'h2o_c': 1.0, 'pep_c': 1.0}
{'6pgl_c': -1.0, 'h2o_c': -1.0, '6pgc_c': 1.0, 'h_c': 1.0}
{'6pgc_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'ru5p__D_c': 1.0}
{'atp_c': -1.0, 'coa_c': -1.0, 'succ_c': -1.0, 'adp_c': 1.0, 'pi_c': 1.0, 'succoa_c': 1.0}
{'co2_c': -1.0, 'h2o_c': -1.0, 'pep_c': -1.0, 'h_c': 1.0, 'oaa_c': 1.0, 'pi_c': 1.0}
{'h_e': -1.0, 'pi_e': -1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'accoa_c': -1.0, 'pi_c': -1.0, 'actp_c': 1.0, 'coa_c': 1.0}
{'g3p_c': -1.0, 'nad_c': -1.0, 'pi_c': -1.0, '13dpg_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'adp_c': -1.0, 'h_e': -4.0, 'pi_c': -1.0, 'atp_c': 1.0, 'h2o_c': 1.0, 'h_c': 3.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'fdp_c': -1.0, 'h2o_c': -1.0, 'f6p_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'6pgl_c': -1.0, 'h2o_c': -1.0, '6pgc_c': 1.0, 'h_c': 1.0}
{'g6p_c': -1.0, 'nadp_c': -1.0, '6pgl_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0}
{'pi_e': -1.0}
{'h_e': -1.0, 'pi_e': -1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'ac_c': -1.0, 'atp_c': -1.0, 'actp_c': 1.0, 'adp_c': 1.0}
{'ac_e': -1.0, 'h_e': -1.0, 'ac_c': 1.0, 'h_c': 1.0}
{'h_e': -1.0, 'pyr_e': -1.0, 'h_c': 1.0, 'pyr_c': 1.0}
{'adp_c': -1.0, 'h_c': -1.0, 'pep_c': -1.0, 'atp_c': 1.0, 'pyr_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'fru_e': -1.0, 'pep_c': -1.0, 'f6p_c': 1.0, 'pyr_c': 1.0}
{'lac__D_c': -1.0, 'nad_c': -1.0, 'h_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'coa_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'for_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'glc__D_e': -1.0, 'pep_c': -1.0, 'g6p_c': 1.0, 'pyr_c': 1.0}
{'mal__L_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'pyr_c': 1.0}
{'coa_c': -1.0, 'nad_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'co2_c': 1.0, 'nadh_c': 1.0}
{'h_e': -1.0, 'pyr_e': -1.0, 'h_c': 1.0, 'pyr_c': 1.0}
{'pyr_e': -1.0}
{'fum_c': -1.0, 'q8h2_c': -1.0, 'q8_c': 1.0, 'succ_c': 1.0}
{'q8_c': -1.0, 'succ_c': -1.0, 'fum_c': 1.0, 'q8h2_c': 1.0}
{'h_c': -4.0, 'nadh_c': -1.0, 'q8_c': -1.0, 'h_e': 3.0, 'nad_c': 1.0, 'q8h2_c': 1.0}
{'h_c': -2.0, 'o2_c': -0.5, 'q8h2_c': -1.0, 'h2o_c': 1.0, 'h_e': 2.0, 'q8_c': 1.0}
{'fum_c': -1.0, 'q8h2_c': -1.0, 'q8_c': 1.0, 'succ_c': 1.0}
{'q8_c': -1.0, 'succ_c': -1.0, 'fum_c': 1.0, 'q8h2_c': 1.0}
{'h_c': -4.0, 'nadh_c': -1.0, 'q8_c': -1.0, 'h_e': 3.0, 'nad_c': 1.0, 'q8h2_c': 1.0}
{'h_c': -2.0, 'o2_c': -0.5, 'q8h2_c': -1.0, 'h2o_c': 1.0, 'h_e': 2.0, 'q8_c': 1.0}
{'r5p_c': -1.0, 'ru5p__D_c': 1.0}
{'r5p_c': -1.0, 'xu5p__D_c': -1.0, 'g3p_c': 1.0, 's7p_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'r5p_c': -1.0, 'ru5p__D_c': 1.0}
{'6pgc_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'ru5p__D_c': 1.0}
{'ru5p__D_c': -1.0, 'xu5p__D_c': 1.0}
{'ac_e': -1.0, 'h_e': -1.0, 'ac_c': 1.0, 'h_c': 1.0}
{'ac_e': -1.0}
{'etoh_c': -1.0, 'nad_c': -1.0, 'acald_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'acald_e': -1.0, 'acald_c': 1.0}
{'acald_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'accoa_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'r5p_c': -1.0, 'xu5p__D_c': -1.0, 'g3p_c': 1.0, 's7p_c': 1.0}
{'g3p_c': -1.0, 's7p_c': -1.0, 'e4p_c': 1.0, 'f6p_c': 1.0}
{'acald_e': -1.0, 'acald_c': 1.0}
{'acald_e': -1.0}
{'accoa_c': -1.0, 'pi_c': -1.0, 'actp_c': 1.0, 'coa_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'coa_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'for_c': 1.0}
{'accoa_c': -1.0, 'h2o_c': -1.0, 'oaa_c': -1.0, 'cit_c': 1.0, 'coa_c': 1.0, 'h_c': 1.0}
{'coa_c': -1.0, 'nad_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'co2_c': 1.0, 'nadh_c': 1.0}
{'accoa_c': -1.0, 'glx_c': -1.0, 'h2o_c': -1.0, 'coa_c': 1.0, 'h_c': 1.0, 'mal__L_c': 1.0}
{'acald_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'accoa_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'h_e': -2.0, 'succ_e': -1.0, 'h_c': 2.0, 'succ_c': 1.0}
{'q8_c': -1.0, 'succ_c': -1.0, 'fum_c': 1.0, 'q8h2_c': 1.0}
{'atp_c': -1.0, 'coa_c': -1.0, 'succ_c': -1.0, 'adp_c': 1.0, 'pi_c': 1.0, 'succoa_c': 1.0}
{'h_e': -1.0, 'succ_c': -1.0, 'h_c': 1.0, 'succ_e': 1.0}
{'icit_c': -1.0, 'glx_c': 1.0, 'succ_c': 1.0}
{'fum_c': -1.0, 'q8h2_c': -1.0, 'q8_c': 1.0, 'succ_c': 1.0}
{'h_e': -2.0, 'succ_e': -1.0, 'h_c': 2.0, 'succ_c': 1.0}
{'succ_e': -1.0}
{'h_e': -1.0, 'succ_c': -1.0, 'h_c': 1.0, 'succ_e': 1.0}
{'atp_c': -1.0, 'coa_c': -1.0, 'succ_c': -1.0, 'adp_c': 1.0, 'pi_c': 1.0, 'succoa_c': 1.0}
{'akg_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'succoa_c': 1.0}
{'acon_C_c': -1.0, 'h2o_c': -1.0, 'icit_c': 1.0}
{'cit_c': -1.0, 'acon_C_c': 1.0, 'h2o_c': 1.0}
{'e4p_c': -1.0, 'xu5p__D_c': -1.0, 'f6p_c': 1.0, 'g3p_c': 1.0}
{'r5p_c': -1.0, 'xu5p__D_c': -1.0, 'g3p_c': 1.0, 's7p_c': 1.0}
{'ru5p__D_c': -1.0, 'xu5p__D_c': 1.0}
{'ac_c': -1.0, 'atp_c': -1.0, 'actp_c': 1.0, 'adp_c': 1.0}
{'accoa_c': -1.0, 'pi_c': -1.0, 'actp_c': 1.0, 'coa_c': 1.0}
{'atp_c': -1.0, 'coa_c': -1.0, 'succ_c': -1.0, 'adp_c': 1.0, 'pi_c': 1.0, 'succoa_c': 1.0}
{'adp_c': -1.0, 'h_c': -1.0, 'pep_c': -1.0, 'atp_c': 1.0, 'pyr_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'3pg_c': -1.0, 'atp_c': -1.0, '13dpg_c': 1.0, 'adp_c': 1.0}
{'atp_c': -1.0, 'oaa_c': -1.0, 'adp_c': 1.0, 'co2_c': 1.0, 'pep_c': 1.0}
{'atp_c': -1.0, 'f6p_c': -1.0, 'adp_c': 1.0, 'fdp_c': 1.0, 'h_c': 1.0}
{'adp_c': -1.0, 'h_e': -4.0, 'pi_c': -1.0, 'atp_c': 1.0, 'h2o_c': 1.0, 'h_c': 3.0}
{'ac_c': -1.0, 'atp_c': -1.0, 'actp_c': 1.0, 'adp_c': 1.0}
{'amp_c': -1.0, 'atp_c': -1.0, 'adp_c': 2.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'atp_c': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'akg_c': -1.0, 'gln__L_c': -1.0, 'h_c': -1.0, 'nadph_c': -1.0, 'glu__L_c': 2.0, 'nadp_c': 1.0}
{'icit_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'co2_c': 1.0, 'nadph_c': 1.0}
{'akg_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'succoa_c': 1.0}
{'glu__L_c': -1.0, 'h2o_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0, 'nh4_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'akg_e': -1.0, 'h_e': -1.0, 'akg_c': 1.0, 'h_c': 1.0}
{'akg_e': -1.0}
{'akg_e': -1.0, 'h_e': -1.0, 'akg_c': 1.0, 'h_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'amp_c': -1.0, 'atp_c': -1.0, 'adp_c': 2.0}
{'atp_c': -1.0, 'coa_c': -1.0, 'succ_c': -1.0, 'adp_c': 1.0, 'pi_c': 1.0, 'succoa_c': 1.0}
{'adp_c': -1.0, 'h_c': -1.0, 'pep_c': -1.0, 'atp_c': 1.0, 'pyr_c': 1.0}
{'atp_c': -1.0, 'glu__L_c': -1.0, 'nh4_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'gln__L_e': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'gln__L_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'3pg_c': -1.0, 'atp_c': -1.0, '13dpg_c': 1.0, 'adp_c': 1.0}
{'atp_c': -1.0, 'oaa_c': -1.0, 'adp_c': 1.0, 'co2_c': 1.0, 'pep_c': 1.0}
{'atp_c': -1.0, 'h2o_c': -1.0, 'pyr_c': -1.0, 'amp_c': 1.0, 'h_c': 2.0, 'pep_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'f6p_c': -1.0, 'adp_c': 1.0, 'fdp_c': 1.0, 'h_c': 1.0}
{'adp_c': -1.0, 'h_e': -4.0, 'pi_c': -1.0, 'atp_c': 1.0, 'h2o_c': 1.0, 'h_c': 3.0}
{'ac_c': -1.0, 'atp_c': -1.0, 'actp_c': 1.0, 'adp_c': 1.0}
{'amp_c': -1.0, 'atp_c': -1.0, 'adp_c': 2.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'atp_c': -1.0, 'h2o_c': -1.0, 'adp_c': 1.0, 'h_c': 1.0, 'pi_c': 1.0}
{'accoa_c': -1.0, 'h2o_c': -1.0, 'oaa_c': -1.0, 'cit_c': 1.0, 'coa_c': 1.0, 'h_c': 1.0}
{'cit_c': -1.0, 'acon_C_c': 1.0, 'h2o_c': 1.0}
{'icit_c': -1.0, 'nadp_c': -1.0, 'akg_c': 1.0, 'co2_c': 1.0, 'nadph_c': 1.0}
{'co2_c': -1.0, 'h2o_c': -1.0, 'pep_c': -1.0, 'h_c': 1.0, 'oaa_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'oaa_c': -1.0, 'adp_c': 1.0, 'co2_c': 1.0, 'pep_c': 1.0}
{'mal__L_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'pyr_c': 1.0}
{'6pgc_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'ru5p__D_c': 1.0}
{'akg_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'succoa_c': 1.0}
{'co2_e': -1.0, 'co2_c': 1.0}
{'mal__L_c': -1.0, 'nadp_c': -1.0, 'co2_c': 1.0, 'nadph_c': 1.0, 'pyr_c': 1.0}
{'coa_c': -1.0, 'nad_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'co2_c': 1.0, 'nadh_c': 1.0}
{'co2_e': -1.0}
{'co2_e': -1.0, 'co2_c': 1.0}
{'atp_c': -1.0, 'coa_c': -1.0, 'succ_c': -1.0, 'adp_c': 1.0, 'pi_c': 1.0, 'succoa_c': 1.0}
{'accoa_c': -1.0, 'pi_c': -1.0, 'actp_c': 1.0, 'coa_c': 1.0}
{'accoa_c': -1.0, 'h2o_c': -1.0, 'oaa_c': -1.0, 'cit_c': 1.0, 'coa_c': 1.0, 'h_c': 1.0}
{'accoa_c': -1.0, 'glx_c': -1.0, 'h2o_c': -1.0, 'coa_c': 1.0, 'h_c': 1.0, 'mal__L_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'akg_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'co2_c': 1.0, 'nadh_c': 1.0, 'succoa_c': 1.0}
{'coa_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'for_c': 1.0}
{'coa_c': -1.0, 'nad_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'co2_c': 1.0, 'nadh_c': 1.0}
{'acald_c': -1.0, 'coa_c': -1.0, 'nad_c': -1.0, 'accoa_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'dhap_c': -1.0, 'g3p_c': 1.0}
{'fdp_c': -1.0, 'dhap_c': 1.0, 'g3p_c': 1.0}
{'e4p_c': -1.0, 'xu5p__D_c': -1.0, 'f6p_c': 1.0, 'g3p_c': 1.0}
{'g3p_c': -1.0, 's7p_c': -1.0, 'e4p_c': 1.0, 'f6p_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'etoh_e': -1.0, 'h_e': -1.0, 'etoh_c': 1.0, 'h_c': 1.0}
{'etoh_c': -1.0, 'nad_c': -1.0, 'acald_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'etoh_e': -1.0, 'h_e': -1.0, 'etoh_c': 1.0, 'h_c': 1.0}
{'etoh_e': -1.0}
{'g6p_c': -1.0, 'f6p_c': 1.0}
{'e4p_c': -1.0, 'xu5p__D_c': -1.0, 'f6p_c': 1.0, 'g3p_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'fdp_c': -1.0, 'h2o_c': -1.0, 'f6p_c': 1.0, 'pi_c': 1.0}
{'fru_e': -1.0, 'pep_c': -1.0, 'f6p_c': 1.0, 'pyr_c': 1.0}
{'g3p_c': -1.0, 's7p_c': -1.0, 'e4p_c': 1.0, 'f6p_c': 1.0}
{'atp_c': -1.0, 'f6p_c': -1.0, 'adp_c': 1.0, 'fdp_c': 1.0, 'h_c': 1.0}
{'fdp_c': -1.0, 'dhap_c': 1.0, 'g3p_c': 1.0}
{'fdp_c': -1.0, 'h2o_c': -1.0, 'f6p_c': 1.0, 'pi_c': 1.0}
{'atp_c': -1.0, 'f6p_c': -1.0, 'adp_c': 1.0, 'fdp_c': 1.0, 'h_c': 1.0}
{'for_e': -1.0, 'for_c': 1.0}
{'for_e': -1.0, 'h_e': -1.0, 'for_c': 1.0, 'h_c': 1.0}
{'coa_c': -1.0, 'pyr_c': -1.0, 'accoa_c': 1.0, 'for_c': 1.0}
{'for_e': -1.0}
{'for_e': -1.0, 'for_c': 1.0}
{'for_e': -1.0, 'h_e': -1.0, 'for_c': 1.0, 'h_c': 1.0}
{'fru_e': -1.0}
{'fru_e': -1.0, 'pep_c': -1.0, 'f6p_c': 1.0, 'pyr_c': 1.0}
{'q8_c': -1.0, 'succ_c': -1.0, 'fum_c': 1.0, 'q8h2_c': 1.0}
{'fum_c': -1.0, 'h2o_c': -1.0, 'mal__L_c': 1.0}
{'fum_c': -1.0, 'q8h2_c': -1.0, 'q8_c': 1.0, 'succ_c': 1.0}
{'fum_e': -1.0, 'h_e': -2.0, 'fum_c': 1.0, 'h_c': 2.0}
{'fum_e': -1.0, 'h_e': -2.0, 'fum_c': 1.0, 'h_c': 2.0}
{'fum_e': -1.0}
{'dhap_c': -1.0, 'g3p_c': 1.0}
{'fdp_c': -1.0, 'dhap_c': 1.0, 'g3p_c': 1.0}
{'e4p_c': -1.0, 'xu5p__D_c': -1.0, 'f6p_c': 1.0, 'g3p_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
{'g3p_c': -1.0, 'nad_c': -1.0, 'pi_c': -1.0, '13dpg_c': 1.0, 'h_c': 1.0, 'nadh_c': 1.0}
{'r5p_c': -1.0, 'xu5p__D_c': -1.0, 'g3p_c': 1.0, 's7p_c': 1.0}
{'g3p_c': -1.0, 's7p_c': -1.0, 'e4p_c': 1.0, 'f6p_c': 1.0}
{'glc__D_e': -1.0, 'pep_c': -1.0, 'g6p_c': 1.0, 'pyr_c': 1.0}
{'g6p_c': -1.0, 'f6p_c': 1.0}
{'g6p_c': -1.0, 'nadp_c': -1.0, '6pgl_c': 1.0, 'h_c': 1.0, 'nadph_c': 1.0}
{'3pg_c': -1.496, 'accoa_c': -3.7478, 'atp_c': -59.81, 'e4p_c': -0.361, 'f6p_c': -0.0709, 'g3p_c': -0.129, 'g6p_c': -0.205, 'gln__L_c': -0.2557, 'glu__L_c': -4.9414, 'h2o_c': -59.81, 'nad_c': -3.547, 'nadph_c': -13.0279, 'oaa_c': -1.7867, 'pep_c': -0.5191, 'pyr_c': -2.8328, 'r5p_c': -0.8977, 'adp_c': 59.81, 'akg_c': 4.1182, 'coa_c': 3.7478, 'h_c': 59.81, 'nadh_c': 3.547, 'nadp_c': 13.0279, 'pi_c': 59.81}
